Robert Neville is a brilliant scientist; but even he could not contain the terrible virus that was unstoppable; incurable; and man-made. Somehow immune; Neville is now the last human survivor in what is left of New York City and maybe the world. For three years; Neville has faithfully sent out daily radio messages; desperate to find any other survivors who might be out there. But he is not alone. Mutant victims of the plague -- The Infected -- lurk in the shadows... watching Neville's every move... waiting for him to make a fatal mistake. Perhaps mankind's last; best hope; Neville is driven by only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood. But he knows he is outnumbered... and quickly running out of time.